Calcium hydroxide (Ca(OH)2) has been widely used in endodontics as an intracanal medicament to eliminate the remaining microorganisms after chemomechanical preparation.
The release of hydroxyl ions in an aqueous environment is essential for the activation of calcium hydroxide against microbes. These ions reacted intensively with several biomolecules due to their highly oxidant free radicals.
As this reactivity is unspecified, the free radicals most likely gathered at the sites of generation. Hydroxyl ions have fatal effects on bacterial cells. They may damage the cytoplasmic membrane of bacteria, denature their proteins, or damage the DNA.
The Effect of calcium hydroxide on pro-Inflammatory cytokines was studied and concluded that it leads to denaturation of these pro-inflammatory mediators such as interleukin-1 α (IL-1α), tumor necrosis factor α(TNF α) and calcitonin gene-related peptide (CGRP) that is a potential mechanism by which calcium hydroxide contributes to the resolution of periradicular periodontitis.
AvueCal is made up of Calcium Hydroxide, Barium Sulphate & Excipients.